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KMID : 0613820030130060865
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Journal of Life Science
2003 Volume.13 No. 6 p.865 ~ p.870
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Effects of Opuntia ficus-indica on Lipidperoxide and cholesterol level
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Jun Hong-Ki
Jeong Young-kee
Ha Bae-Jin
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Abstract
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Opuntia ficus-indica is widely used as folk medicine for burned wound, edema and indigestion, etc. After the adaptation of rats for seven days, OF (200mg/kg) was administered into rats intraperitoneally every day for two weeks. On the 14th day, 3.3㎖ of CCl₄(50% CCl₄ : Olive oil = 1 : 1) was treated to rats and on the 15th day, they were operated. We measured the levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, total lipid and triglyceride (TG) in serum and Malondialdehyde (MDA) in liver tissue. Opuntia ficus-indica and CCl₄-treated group (OFC) significantly decreased lipid peroxidation by 32.6% compared to CCl₄-treated abnomal group (CTA). Total lipid and TG of OFC administered group were lower than those of CTA group. Cholesterol levels showed significant effect in OFC group. Total cholesterol and LDL-cholesterol in OFC administered group were decreased by 12.7% and 17.4%, respectively, compared to those of CTA group. HDL-cholesterol in OFC administration group was increased by 19.7% compared to CTA group. This finding suggests that lipid peroxidation was inhibited in the significant level when CCl₄-induced rats were treated with OF. Based on this analysis, further study to identify the active components in this sample is warranted.
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KEYWORD
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Opuntia ficus-indica, CCl4, Lipidperoxide, Cholesterol, Hepatotoxicity
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